The mission of the Laboratory of Animal Models is the generation and analysis of  animal models. Our main goal is to determine the effect of genetic modification on the behavior and metabolism of the tested animal. Laboratory has latest technology equipment for the production of genetically modified animals and then to study the so-produced models.

In addition, the laboratory serves as a "core-facility”.  The facility provides services for the production of genetically modified animals and viral vectors. We offer service to scientific and R&D institutions worldwide.

                                                                 

Our current research profile:

Studies carried out in the Laboratory Animal models are features of non-coding RNA, in particular microRNA-dependent protein Dicer in various brain regions and peripheral tissues. We focus on two major issues:

• The role of microRNA in synaptic plasticity of neurons involved in the formation of the memory trace. In particular, we are looking for microRNAs involved in the regulation of translation neurotrophic factor BDNF. We have recently shown the impact of such microRNA on enhancement of  learning and memory (Konopka et al., 2010).

• The role of microRNA in the neurons of the peripheral tissues and tissues involved in the development of metabolic syndrome in mice.  We are  focused on investigating  microRNA involved in the regulation of translation of genes present path signal transduction leading from the insulin receptor kinase mTOR. This path is responsible for the regulation of cellular metabolism in response to the availability of nutrients.

 

In Laboratory of Animal Models we perform: